Many people who use PO boxes do not realize that a virtual mailbox solution exists. What is the difference between a PO box and a virtual mailbox? A virtual mailbox is different than a PO box in a number of ways. Virtual mailboxes can be used to receive package deliveries, as an official registered address for businesses, and would not require you to physically visit the PO box to check your mail. PO boxes are managed by the USPS and come with a number of restrictions. Virtual mailboxes are privately run in conjunction with USPS mail regulations. Virtual mailbox services such as Scan Mailboxes is a great way to manage your mail.